Synthesis and antimicrobial studies of some Mannich bases carrying imidazole moiety
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چکیده
منابع مشابه
Synthesis and antimicrobial studies of some Mannich bases carrying imidazole moiety.
3 Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl- 4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione () was synthesized and was subjected to Mannich reaction with appropriate amines to yield a new series of 3-substituted aminomethyl-5-(2-methyl-4-nitro-1-imidazomethyl)- 1,3,4-oxadiazole-2-thiones (4a-j). The structure of the title compounds was elucidated by elemental analysis and sp...
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The amino alkylation of aromatic substrates by the Mannich reaction is of considerable importance for the synthesis and modification of biologically active compounds. The Mannich derivatives of 2-Chloro 4nitrobenzamide with formaldehyde and various secondary amines were synthesized for study of their biological effects. The structures of the synthesized compounds were assigned on the basis of e...
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(1,4,5-Triphenylimidazol-2-yl-thio)butyric acid hydrazide (3) was obtained via alkylation of 1,4,5-triphenylimidazol-2- thiol (1) with ethylbromobutyrate, followed by addition of hydrazine hydrate. Treatment of acid hydrazide 3 with carbon disulfide in an ethanolic potassium hydroxide solution gave the intermediate potassium dithiocarbazinate salt, which was cyclized to 4-amino-5-[(1,4,5-triphe...
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ژورنال
عنوان ژورنال: Acta Pharmaceutica
سال: 2013
ISSN: 1846-9558,1330-0075
DOI: 10.2478/acph-2013-0016